Applications for the Division of Infectious Diseases Fellowship Program are accepted only through the Electronic Residency Application Service (ERAS). 

Division of Infectious Diseases
Department of Internal Medicine
1 University of New Mexico
Albuquerque, New Mexico 87131
Phone: (505) 272-5666
Fax: (505) 272-4435

Laboratory of Fungal Pathogenesis

Division of Infectious Disease
Laboratory of Fungal Pathogenesis

Samuel A. Lee, MD, PhD

Samuel A. Lee

Section Chief, Infectious Diseases


VA Albuquerque Medical Center
1501 San Pedro Dr. SE
Mail Code: 111-J
Albuquerque, NM 87108

Office: (505) 265-1711 ext 2488
Lab: (505) 265-1711 ext 3379

Laboratory Shipping Address:
Research 151, Bldg 12
1501 San Pedro Dr SE
Albuquerque, NM 87108

Lab Phone: (505) 265-1711, ext 3378 or 4661
Lab Fax: (505) 256-2803

Our laboratory studies the molecular pathogenesis of invasive candidiasis and also investigates translational aspects of Candida infection, including mechanisms of biofilm formation, and echinocandin resistance.

A major objective of our laboratory is to define the secretory pathways of secreted virulence proteins and determine if mutations in these pathways have an effect on biofilm formation and virulence in vivo.

Our laboratory is currently studying loss-of-function mutations in several VPS (vacuole protein sorting) genes and their effects on aspartyl protease secretion, filamentation, biofilm formation, and in vivo virulence. This work is supported by a Department of Veterans Affairs MERIT award.

A second major focus of our laboratory is identification of novel secretory proteins in C. albicans and their role in virulence, using bioinformatic, genomic, and proteomic approaches. An additional goal is to identify novel markers of invasive candidiasis, as current diagnostic methods for invasive candidiasis remain sub-optimal.

Our lab is also involved in translational research on novel antifungal therapies and treatment approaches against biofilm formation in Candida species, collaborative studies of echinocandin-resistance in clinical Candida isolates, and the molecular epidemiology of oral candidiasis.